Dr David Holmes (a Principal Engineer at Sphere Fluidics) and collaborators at University College London, University of Cambridge, University of Erlangen and the Technical University Dresden have just published a paper in the Royal Society’s journal Interface Focus. Dr Holmes (lead author on the paper) commented: “This work demonstrates a method for separating cells based on differences in their mechanical phenotype (i.e. stiffness). Cell stiffness was independently measured using optical stretching techniques and was demonstrated to correlate with cell separation in the microfluidic device. This work, taken together with recent numerical modelling work, will contribute to the development of devices for deformability-based separations for disease diagnostics and biological sample preparation.” The title of the paper is: “Separation of blood cells with differing deformability using deterministic lateral displacement.” The article was published here.
Dr David Holmes (a Principal Engineer at Sphere Fluidics) and collaborators at University College London and University of Edinburgh have just published a paper in the online journal Biomicrofluidics. Dr Holmes commented: “This exciting work uses three-dimensional (immersed-boundary-finite-element-lattice-Boltzmann) simulations to investigate how blood cells flow in complex microfluidic geometries. Our work should contribute to the development of devices for deformability-based particle separation; that could be applied to the label-free mechanical detection of malaria-infected RBCs, as well as other diseases.” The title of the paper is: “Deformability-based red blood cell separation in deterministic lateral displacement devices – A simulation study.” The article was published in Biomicrofluidics here.