Our FRET-based assays let you measure antibody secretion accurately at the single cell level and thus make robust selection of high-value cells. FRET (Foster Resonance Energy Transfer) uses two probes, one targeted to the Fc region and one to the antigen-specific region, each labelled with a fluorophore. In the presence of the antibody, the two probes bind bringing the fluorophores close so laser excitation of the donor fluor results in resonance that excites the acceptor probe.

Picodroplets provide a uniquely protective environment to maintain cell viability during incubation and sorting, even when moving at high speeds through microfluidic channels. Our biocompatible surfactants used to make droplets allow high rates of gas exchange to improve post-sorting cell outgrowth.

Large populations are no longer a problem. Screen millions of cells for antigen-specific antibody secretion in a day: with literally every single cell individually assessed and characterized.

All the process steps you need in one platform: cell encapsulation with assay reagents, incubation, secretion assessment, cell selection, monoclonality check, and dispensing into microwell plates all in one – all completely hands-off along with all supporting data. Each run uses a disposable cartridge to eliminate any cleaning or concerns about cross-contamination between runs.