Cyto-Mine® is our high-throughput platform using picodroplet technology and microfluidics to process up to 40 million heterogeneous mammalian cells (in pools) in less than a day! While principally designed for antibody discovery and cell line development, Cyto-Mine® is an extremely flexible platform, making it ideal for a wide variety of application areas.
Cyto-Mine®: Accelerating Antibody Discovery and Cell Line Development
Streamline your workflows like never before.
Cyto-Mine® is a state-of-the-art, automated platform designed to revolutionize biopharmaceutical discovery and cell line development. By integrating advanced technologies, Cyto-Mine® simplifies and accelerates the entire cell line development process, from cell encapsulation and assay integration to monoclonality assurance and high-throughput screening.
A unique and gentle workflow to find those rare gems
Watch Cyto-Mine® in action
Accelerate Cell Research with Picodroplets
Cells are encapsulated in picodroplets containing growth media, which act as a bioreactor to compartmentalize cells allowing their growth and eventual trapping of secreted molecules such as antibodies. Our unique workflow enables selective screening of single cells to find your rare lead candidates.
Ensure Monoclonality and Protect Your Cells
Monoclonality is ensured when single cells are compartmentalized in individual picodroplets, allowing you to perform novel assays, determining protein secretion rates, titre and antigen-specificity. Capturing single cells in picodroplets also ensures gentle processing throughout the workflow, protecting your important cells.
Sterile, Automated, and GLP-Compliant Solutions
Each run takes place within our disposable Cyto-Cartridge® giving you confidence of sterility while minimising crossover risks. The automation of Cyto-Mine® reduces human workload and our simple ‘load-and-go’ system streamlines work for everyone in the lab. Cyto-Mine®, Cyto-Cartridge® and our specialist chemicals and bioreagents are all Animal Origin Free and GLP-compliant.
Next Generation Technology
Current processes for finding novel antibody targets or developing stable cell lines are time-consuming, often inefficient, and difficult to scale. Cyto-Mine® breaks down the barriers that current processes can bring, such as low throughput, or imposing harsh conditions on cells impacting viability and outgrowth, or not allowing direct measurement of cell secretion. Our platform provides the next generation of technology to provide automated, accurate, cost-effective high-throughput screening with gentle processing and reduced contamination.
Discover our Cyto-Cellect®PLUS FRET assay application note
Cyto-Cellect®PLUS detects the presence of human IgG kappa and lambda light chains, compatible with the Cyto-Mine®.
Cyto-Cellect®PLUS Application note
With Cyto-Mine® you can achieve:
Targeted Discovery
Rapidly identify and isolate your rare cells of interest.
Rapidly identify and isolate your rare cells of interest.
Monoclonality Assurance
Extensive proof of monoclonality is critical for cell line development.
Extensive proof of monoclonality is critical for cell line development.
Save Time and Costs
Tens of millions of cells in pools or hundreds of thousands individually can be screened in a single day.
Tens of millions of cells in pools or hundreds of thousands individually can be screened in a single day.
Flexibility
Flexible assay designs allow quantitative measurement of antibody secretion and other detection methodologies.
Flexible assay designs allow quantitative measurement of antibody secretion and other detection methodologies.
GLP Compliance
The entire process is automated utilizing Animal Origin Free reagents. The Benchtop system is compatible for use in Class II biosafety cabinets.
The entire process is automated utilizing Animal Origin Free reagents. The Benchtop system is compatible for use in Class II biosafety cabinets.
Regulatory Compatibility
Cyto-Mine® is 21 CFR Part 11-compliant.
Cyto-Mine® is 21 CFR Part 11-compliant.
What customers are saying
“Cyto-Mine® can generate cell lines with high productivity, good viability, and a strong assurance of monoclonality after a single round of screening.”
Thomas Kelly
Janssen R&D, USA
“Our workflows are considerably more efficient as cellular screening is conducted early in the process, allowing the best-performing cells to be selected and taken forward for development”
Dr Fay Saunders
FUJIFILM Diosynth Biotechnologies
“The integration of Cyto-Mine® into our cell line development workflows enables us to provide high-quality, customized cell lines in a fraction of the time.”
António Barroso, Head of Cell Development Division
FairJourney Biologics
Find, analyze and isolate your most valuable cells, with ease and speed
Flexible Assay Design
Cyto-Mine® enables a wide range of fluorescence-based miniaturized assays of target proteins with high sensitivity and specificity. The assay format can also be tailored to suit your specific project needs.
Evidence of Monoclonality
Cyto-Mine®’s built-in imaging and image analysis software provides documented proof of monoclonality for each selected cell (> 99% confidence).
Single Cell Assays
Cyto-Mine® picodroplet technology enables a powerful way to screen vast quantities of cells and molecules of interest. Our platform offers an optimized set-up for your single cell analysis needs.
Learn more about Cyto-Mine®
Discover the Cyto-Cartridge®
The Cyto-Cartridge® is the core of the Cyto-Mine® platform, providing all the necessary microfluidics for implementing picodroplet workflows.
The disposable cartridge is designed to be easy-to-use, ensuring zero cross-contamination between runs and maintaining the integrity and quality of your cells for each experiment.
Cyto-Cartridges® are manufactured from fully biocompatible materials under
our ISO 9001 quality management system, in a clean environment.
Explore the Cyto-Mine® Platform in AR
Built on picodroplet technology
At the heart of our platforms are picodroplets. These are tiny droplets of aqueous fluid in an oil carrier fluid (‘single aqueous’), or an aqueous core surrounded by an oil shell in an aqueous carrier fluid ( ‘double aqueous’).
Each picodroplet is used to encapsulate a cell. This provides an ultra-miniaturized test tube, containing media, reagents and cells, that allows large-scale experiments at the single cell level.
These droplets can then be processed to build complex workflows to find the cells you care about.
How to think big
Picodroplets have numerous applications in life science R&D. Here are some examples to fire up your imagination.
Consumables and Reagents
Our teams have created an ecosystem of high-quality consumables and reagents optimized for use with Cyto-Mine® to ensure that your workflows are as efficient as possible.
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Cyto-Cellect® Human IgG Kappa and Viability Assay Kit
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Cyto-Cellect® Fc Fusion Assay Kit
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Cyto-Cellect® Mouse (Mouse IgG Detection Kit)
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Cyto-Cellect®PLUS Assay Kit (Human IgG κ and λ Detection (AOF) Range)
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Cyto-Cellect® Probes (Cyto-Cellect® Human IgGκ Detection Kit)
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Cyto-Cartridge®
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Cyto-Surf® B
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Cyto-Surf® A
