Cell Line Development
Optimize your cell line development with picodroplet precision
Effortlessly identify and isolate your highest-producing cells with our cutting-edge automated solutions. Elevate your research with speed and precision, powered by picodroplet technology. Learn more about Cyto-Mine® and see how our innovative platform can streamline your workflows, ensuring high throughput and gentle handling for exceptional viability and growth.
Increase efficiency
Do you wish there was an easier way to ensure only your highest-producing cells are progressed? Our platforms find the high producers and gently isolate them – automatically.
- Fully integrated automated workflows
- Screen large cell populations easily
- Select and dispense directly into well plates
- Built-in monoclonality assurance
Find your best possible cells – easily
Integrated and automated cell line development workflow
Everything you need in one platform
Experience a seamless cell line development workflow with our platform. All the process steps you need – cell encapsulation with assay reagents, incubation, assessment, cell selection, monoclonality check, and dispensing into microtiter plates – are all in one place. Our hands-off approach, along with comprehensive supporting data, ensures efficiency and accuracy. Each run uses a disposable cartridge to eliminate cleaning or cross-contamination concerns between runs.
Optimizing CHO cell line development for high producers and great growth
Ensuring you achieve both goals
In the cell line development process, it’s crucial not only to find high producers but also to ensure strong outgrowth for fed-batch screening. Our picodroplets protect cells during processing and allow high gas transfer rates, resulting in high cell viability. Data shows that picodroplets are equivalent to limiting dilution in 96 well plates for the outgrowth of CHO cells, optimizing your cell line development.
High throughput and gentle processing for cell line research
Lightning fast without stress
Achieve the perfect balance for your cell line research. Traditional flow cytometry offers high throughput but can cause intense shear stresses that damage cells. Clone pickers are gentle but slow. Our picodroplets provide speed (up to 200,000 cells per day) while protecting cells, ensuring your high-value clone is not stressed or damaged. Data shows >97% viability for two different CHO cell lines 24 and 48 hours after processing with Cyto-Mine®.
Assuring monoclonal cell line development
There can be only one
Regulations demand evidence that a cell line is derived from a single cell progenitor or clone. Our Cyto-Mine® instrument automatically records and analyzes images of cells in droplets to assess monoclonality before dispensing. Multiple images, taken as the droplet moves and rotates in the channel, give the best possible chance to identify droplets with more than one cell and exclude them from downstream processing, assuring the development of a monoclonal cell line.
Advanced HEK cell line development optimization
Achieve excellence with precision
Optimize your HEK cell line development with our advanced platform. Our picodroplet technology supports high viability and precise cell selection, ensuring that your HEK cells thrive through every stage of the development process. From initial encapsulation to final selection, our workflow is designed to enhance the efficiency and success of your cell line development.
Built on picodroplet technology
At the heart of our platforms are picodroplets – picolitre-volume aqueous droplets in a carrier oil. Each droplet acts as a tiny separate test tube. Cells are encapsulated in droplets with the assay reagents and passed through microfluidics for sorting and dispensing. Miniaturized, high-speed and fully automated to streamline your application.
What customers are saying
“Our workflows are considerably more efficient as cellular screening is conducted early in the process, allowing the best-performing cells to be selected and taken forward for development.”
Dr Fay Saunders
FUJIFILM Diosynth Biotechnologies
“The integration of Cyto-Mine® into our cell line development workflows enables us to provide high-quality, customized cell lines in a fraction of the time.”
António Barroso, Head of Cell Development Division
FairJourney Biologics
The Next Generation: Cyto-Mine® Chroma
Automate. Accelerate. Analyze millions of cells in a single day.
Think Cyto-Mine®, but supercharged, enabling multiplexing and greater assay flexibility to fit your needs. It means that you can examine vastly greater numbers of cells — and isolate the most valuable ones— with unparalleled precision.
We’re the droplet microfluidic technology company for single cell analysis and our customers are at the center of what we do
Our integrated,
automated platforms
increase efficiency,
delivering value.
Our unmatched
picodroplet technology
is future proof
Our platform is built upon robust evidence from key opinion leaders
Our collaboration with customers is
second to none
Have a question for us?
Our team of experts are on hand to provide you with the information and support you need. Whether you have a question about our products, services or training, we're always happy to assist you
Contact us
