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High-Throughput Monoclonality and Cell Line Screening with Cyto-Mine® Technology

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High-Throughput Monoclonality and Cell Line Screening with Cyto-Mine® Technology

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SLAS 2024 Microscale Innovation in Life Sciences Symposium

Summary

Explore how the Cyto-Mine® platform transforms workflows in biomanufacturing and cell line development by combining high-throughput screening, precise monoclonality assurance, and automated single-cell dispensing in one system. In this featured study, researchers show how Cyto-Mine®’s picodroplet technology enables efficient isolation and analysis of high-producing cells, streamlining complex processes from clone selection to biotherapeutic production. Discover how picodroplet microfluidics offers a significant edge in monoclonality and productivity for bioprocessing.

Research highlights

  • Study Title: Cyto-Mine: An Integrated, Picodroplet System for High-Throughput Single-Cell Analysis, Sorting, Dispensing, and Monoclonality Assurance’ SLAS Technology
  • Authors: Dimitris Josephides, Serena Davoli, William Whitley, Raphael Ruis, Robert Salter, Sinan Gokkaya, Maeva Vallet, Darren Matthews, Giuseppe Benazzi, Elena Shvets, Frank Gesellchen, Drew Geere, Xin Liu, Xin Li, Benedict Mackworth, William Young, Zachary Owen, Clive Smith, Dale Starkie, James White, Bernie Sweeney, Matthew Hinchliffe, Simon Tickle, Daniel J. Lightwood, Marian Rehak , Frank F. Craig and David Holmes
  • Published In: SLAS Technology, 2020

Key findings

  • Efficient monoclonality assurance via high-throughput picodroplet technology
  • Rapid cell analysis, sorting, and dispensing in one compact system
  • Applications in genome editing, biomanufacturing, and single-cell diagnostics

The Next Generation: Cyto-Mine® Chroma

Automate. Accelerate. Analyze millions of cells in a single day.

Think Cyto-Mine®, but supercharged, enabling multiplexing and greater assay flexibility to fit your needs. It means that you can examine vastly greater numbers of cells — and isolate the most valuable ones— with unparalleled precision.

Cyto-Mine® Chroma
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