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Cell Line Development

cell line development applications
cell line development applications

Cell Line Development

Optimize your cell line development with picodroplet precision

Effortlessly identify and isolate your highest-producing cells with our cutting-edge automated solutions. Elevate your research with speed and precision, powered by picodroplet technology. Learn more about Cyto-Mine® and see how our innovative platform can streamline your workflows, ensuring high throughput and gentle handling for exceptional viability and growth.

Increase efficiency

Do you wish there was an easier way to ensure only your highest-producing cells are progressed? Our platforms find the high producers and gently isolate them – automatically.

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  • Fully integrated automated workflows
  • Screen large cell populations easily
  • Select and dispense directly into well plates
  • Built-in monoclonality assurance

Built on picodroplet technology

At the heart of our platforms are picodroplets – picolitre-volume aqueous droplets in a carrier oil. Each droplet acts as a tiny separate test tube. Cells are encapsulated in droplets with the assay reagents and passed through microfluidics for sorting and dispensing. Miniaturized, high-speed and fully automated to streamline your application.​

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Find your best possible cells – easily

Integrated and automated cell line development workflow

Everything you need in one platform

Experience a seamless cell line development workflow with our platform. All the process steps you need – cell encapsulation with assay reagents, incubation, assessment, cell selection, monoclonality check, and dispensing into microtiter plates – are all in one place. Our hands-off approach, along with comprehensive supporting data, ensures efficiency and accuracy. Each run uses a disposable cartridge to eliminate cleaning or cross-contamination concerns between runs.

Optimizing CHO cell line development for high producers and great growth

Ensuring you achieve both goals

In the cell line development process, it’s crucial not only to find high producers but also to ensure strong outgrowth for fed-batch screening. Our picodroplets protect cells during processing and allow high gas transfer rates, resulting in high cell viability. Data shows that picodroplets are equivalent to limiting dilution in 96 well plates for the outgrowth of CHO cells, optimizing your cell line development.

High throughput and gentle processing for cell line research

Lightning fast without stress

Achieve the perfect balance for your cell line research. Traditional flow cytometry offers high throughput but can cause intense shear stresses that damage cells. Clone pickers are gentle but slow. Our picodroplets provide speed (up to 200,000 cells per day) while protecting cells, ensuring your high-value clone is not stressed or damaged. Data shows >97% viability for two different CHO cell lines 24 and 48 hours after processing with Cyto-Mine®.

High throughput and gentle chart

Assuring monoclonal cell line cevelopment

There can be only one

Regulations demand evidence that a cell line is derived from a single cell progenitor or clone. Our Cyto-Mine® instrument automatically records and analyzes images of cells in droplets to assess monoclonality before dispensing. Multiple images, taken as the droplet moves and rotates in the channel, give the best possible chance to identify droplets with more than one cell and exclude them from downstream processing, assuring the development of a monoclonal cell line.

Monoclonality assured

Advanced HEK cell line development optimization

Achieve excellence with precision

Optimize your HEK cell line development with our advanced platform. Our picodroplet technology supports high viability and precise cell selection, ensuring that your HEK cells thrive through every stage of the development process. From initial encapsulation to final selection, our workflow is designed to enhance the efficiency and success of your cell line development.

Seeing is believing in cell line development

Don’t take our word for it – witness the power of our cell line development technology in action. We provide demos and proof-of-concept projects to showcase how our platforms can revolutionize your cell line development process.

  • On-site demos or visit us in Cambridge, UK: Experience our cutting-edge technology firsthand, either at your location or at our state-of-the-art facility.
  • Flexible assay options: Utilize our comprehensive range of cell lines and assays, or bring your own to see the results.
  • Innovative proof-of-concept projects: Explore new possibilities and innovative approaches in cell line development.

By providing hands-on demonstrations and custom proof-of-concept projects, we help you build confidence in the capabilities and benefits of our platform for optimizing your cell line development workflow.

Resources & insights

What customers are saying

Custom research solutions projects

We’re the droplet microfluidic technology company for single cell analysis and our customers are at the center of what we do

Our integrated,
automated platforms
increase efficiency,
delivering value.
Our unmatched
picodroplet technology
is future proof
Our platform is built upon robust evidence from key opinion leaders
Our collaboration with customers is
second to none

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