Mammalian Libraries and Microfluidics: Enhancing Antibody Discovery with Novel Functional Screening
Summary
Explore the latest advancements in antibody discovery with a groundbreaking study that combines mammalian libraries and microfluidic technologies to streamline therapeutic antibody development. This innovative approach leverages mammalian libraries for broad antibody diversity and high-throughput screening, offering a unique “display-to-secretion” switchable system for pre-selecting antibody candidates. Learn how our Cyto-Mine® technology contributes to the identification of antibodies with optimized functionality and manufacturability in this high-impact publication.
Research highlights
- Study Title: Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening
- Authors: Ramona Gaa, Hannah Melina Mayer, Daniela Noack, Kavita Kumari, Ralf Guenther, Shang-Pu Tsai, Qingyong Ji & Achim Doerner
- Published In: mAbs, 2023
- DOI: 10.1080/19420862.2023.2251190
Key findings
- Benefits of autocrine screening for functional cell assays
- Advantages of mammalian libraries for antibody pre-selection
- Cyto-Mine®’s role in synchronized high-throughput screening
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