Senior Scientist - Biology

Who are we? Sphere Fluidics is an established Life Science company which provides instruments and specialist consumables for the global pharmaceutical and academic research community. Built upon our picodroplet microfluidic technology, we aim to ease the journey to discovery for single cell analysis and isolation.

 What’s our vision? To be the droplet microfluidic technology company for single cell analysis.

What’s our mission? To find, analyse and isolate the most valuable cells with ease and speed.

What’s our culture? We prioritise a culture that fosters care, collaboration, and self-expression. We believe in continuous learning and improvement and hold ourselves accountable for maintaining integrity at all times. It is our priority to build an inclusive environment that supports growth and empowers our employees to achieve their full potential and role model our employee values:

• We value and care for our people
• We innovate to create our future
• We collaborate and win together as a team

 

What you’ll do

Specific job duties:

• Design, develop and optimize biochemical and cell-based assays for target protein characterization and screening purposes.
• Design and implement protein labelling techniques such as fluorescent labelling, biotinylation, and enzymatic conjugation to develop novel assay formats.
• Collaborate cross-functionally with other research teams to deliver assigned projects.
• Analyze assay data, troubleshoot, and propose innovative solutions to improve assay performance and robustness.
• Contribute to writing documentation (user guides, protocols, etc.) for newly developed assays/products.
• Stay abreast of the latest scientific advancements and technologies in the field of assay development, protein engineering, and drug discovery.

What we’re looking for

Essential

• Ph.D. in Biochemistry, Molecular Biology, Immunology, or a related field with a minimum of 3 years of relevant industry experience.
• Proven track record of success in developing and optimizing robust biochemical and cell-based assays to detect and quantify cellular secretion

• In- depth knowledge of antibody structure and associated formats such as bispecific antibodies.

• Systematic, methodical approach to assay design, implementation and data analysis
• Extensive hands-on experience in protein labelling techniques, including but not limited to fluorescent labelling, biotinylation, and site-specific conjugation.
• Aseptic cell culture technique, and relevant applications (for example, viability, proliferation, cell-based assays etc).
• Prior experience in conducting multi-colour fluorochrome assays for multiplexed applications
• Excellent communication skills with the ability to collaborate effectively in a multidisciplinary team environment.
• Team-orientation toward collaboration and mutual success
• Ability to ensure reproducible and transferable work through use of appropriate procedures and documentation.

Desirable:

• Knowledge of cell line development techniques and experience in establishing stable cell lines expressing recombinant proteins will be advantageous.
• Familiarity with drug discovery processes.
• Knowledge of single cell isolation, microfluidic droplet generation, assay development for protein characterisation in droplets will be desirable.

 

The Benefits

• 25 days holiday plus bank holidays
• Employee Share Options (EMI Scheme)
• Company pension scheme with Aviva (employer contributes 8%)
• 4x Life Insurance & Critical Illness Cover
• Private Medical Insurance with Vitality
• Health Cash Plan
• Group Income Protection
• Employee Assistance Program
• Cycle to Work scheme
• Learning & Development opportunities for career growth
• Long Service Bonus – up to 5 extra days holiday
• Recruitment referral scheme (£1,000)
• Flexible working hours to support work-life balance

 

What’s Next? We will review your application and whilst we would love to get back to every applicant, it is not always possible. If you haven’t heard from us within 4 weeks, please note that your application has not been successful on this occasion.

Sphere Fluidics strives to be an equal opportunities employer. Our policy is to recruit a diverse workforce and follow the guidelines of the Equality Act